Guangzhou holds circular RNA Research Forum

The 5th circular RNA Research Forum is held in the Guangzhou High-Tech Industrial Development Zone from Aug 3 to 4, in Guangzhou, capital of Guangdong province. [Photo provided to chinadaily.com.cn]

The forum focused on six issues about circRNA. They involved the latest progress of circRNA clinical research, research progress in functional circRNA, research progress of the relationship between circRNA and diseases, research on the function of circRNA-encoded polypeptide, circRNA interaction molecule research techniques and methods, and circRNA knockout technology and strategy and new molecular tools based on circRNA.

Professor Burton B. Yang from the University of Toronto in Canada delivers a speech. [Photo provided to chinadaily.com.cn]

Professor Burton B. Yang from the University of Toronto in Canada made a speech titled "Promotion of tumor progression by exosome transmission of circularRNA". His speech made a systematic review of circRNA function research, and then introduced the latest research findings of his team. They discovered that circ-Ska3 promotes the formation of pseudopodia in breast cancer cells by interacting with Tks5 and integrinb1 and can be packaged into exosomes to promote cell invasion.

Zhang Nu, associate professor of the First Affiliated Hospital of Sun Yat-sen University, gives a speech on "The discovery and biological roles of coding circular RNA in gliomatumorigenesis". [Photo provided to chinadaily.com.cn]

Zhang Nu, associate professor of the First Affiliated Hospital of Sun Yat-sen University, gave a speech on "The discovery and biological roles of coding circular RNA in gliomatumorigenesis". He systematically introduced circRNAs capable of translating polypeptides or proteins that have been reported to date and introduced how to analyze and define whether a circular RNA can be translated with knowledge of the circular RNA translation process, gained through Ribosome profiling, IRES and ORF prediction and analysis and the detection of translated outcomes. He also introduced his team's newest findings about a sort of translatable circular RNA that comes from Akt3.

Yao Honghong from the School of Medicine, Southeast University, delivers a speech titled "Circular RNA and Neuroinflammation: Implications for depression treatment". [Photo provided to chinadaily.com.cn]

Professor Yao Honghong from the School of Medicine, Southeast University, delivered a speech titled "Circular RNA and Neuroinflammation: Implications for depression treatment".

She highlighted their newly reported research work on circDYM in depression and discovered that circDYM was significantly reduced in both peripheral blood of patients with depression and in laboratory mice. Through competing combination with miR-9, circDYM could regulate the activity of HECTD1 and promote the expression of HECTD1 to inhibit excessive activation of microglia. Therefore, circDYM could be used as a key therapeutic target for depression.

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