Recently, the natural products Category 1.1 innovative drug Xianglei Tangzu Cream (Fespixon Cream) of Oneness Biotech Co., Ltd. was approved for marketing with conditions by China NMPA. This drug is used for treating Wagner grade 1 diabetic foot ulcer (DFU) with wound cross-sectional area less than 25cm2 after debridement. The marketing of this drug provides a new treatment option for patients with Wagner grade 1 DFU.