Eukaryotic cells have two membrane transport systems, secretion and endocytosis, which are precisely spatiotemporally regulated. Their steady-state operations are crucial for animal development, tissue homeostasis and cancer invasion.

Secretory proteins conventionally enter the endoplasmic reticulum with the help of signal peptides and are transported to the plasma membranes or extracellular spaces through Golgi apparatus. However, many membrane proteins and soluble proteins lacking a typical signal peptide take an unconventional way in secretory transport.

By contrast, cargo-specific endocytosis internalizes plasma membrane proteins and lipids and delivers them to different target organelles after sorting.

Recent studies have shown that unconventional pathways widely exist in the process of the endocytosis and subsequent sorting and transportation including the cargo-specific endosome subpopulation mediated transportation and new interactions between endosomes and specialized organelles. The above unconventional transportation processes reveal urgent scientific problems such as the identification of new organelles and the mechanism of cargo selection.

The session will focus on the cargo selection mechanism and specific regulation of unconventional secretory transport and unconventional endocytic transport.

Chairmen

Shi Anbing

Professor, Huazhong University of Science and Technology

Masataka Yanagawa

Research fellow, Riken, Japan

Invited speakers & reports

Zhang Min

Research fellow, Tsinghua University

Report: Regulation of unconventional secretion by coronavirus factors

Lu Yao

Research fellow, Dalian Institute of Chemical Physics, Chinese Academy of Sciences

Report: Analysis of intercellular interactions with single-cell secretomic analysis microchip

Lin Long

Associate professor, Huazhong University of Science and Technology

Report: RAB-8-dependent unconventional protein secretion in C. elegans

Yuji Hara

Professor, School of Pharmaceutical Sciences, University of Shizuoka

Report: Role of the mechanosensing machinery in myogenesis

Shunsuke Shimobayashi

Research fellow, Prof. Clifford P. Brangwynne Lab, Princeton University

Report: Liquid phase condensation in living cells

Masataka Yanagawa

Research fellow, Riken, JST PRESTO

Report: Single-molecule imaging analysis of G protein-coupled receptor signalosome