Enhancing the 3D growth of skeletal muscle myoblast and the formation of myotube is a difficult issue in recovery and regeneration of skeletal muscle tissues. Professor Guo Baolin’s team of the XJTU Bio-Engineering and Regeneration Research Center at Frontier Institute for Science and Technology proposed a new solution, in which an original material method was employed to mimic skeletal muscle tissues.

Based on this, the PhD students Wang Ling and Wu Yaobin of the research team published in the prestigious nanomaterials journal ACS Nano (the impact factor is 12.881) the paper Nanober Yarn/Hydrogel Core-Shell Scafoolds Mimicking Native Skeletal Muscle Tissue for Guiding 3D Myoblast Alignment, Elogation, and Differentiation.

The research employed nanofibers and photocuring gels in creation of nano-fiber and hydrogel scaffolds mimicking skeletal muscle tissues. The nano-fiber structures in the scaffolds could facilitate the 3D skeletal muscle myoblast alignment and differentiation, while the photocuring gel created an ideal context for growth and nutrition delivery of myoblast. The scaffolds simulate the normal skeletal muscles tissues and provides a new solution to its recovery.