A PhD student Wang Sijia of the bio-medicine-optics research team at School of Life Science and Technology published her paper Light-controlled delivery of monoclonal antibodies for targeted photoinactivation of Ki-67 in the reputable pharmaceutical journal Molecular Pharmaceutics, run by the American Chemical Society; the impact factor in 2014 is 4.78.

The paper employed the latest light-controlled drug importation and delivery technique as well as the photochemical internalization to enable the delivery and target of photo-immune conjugates, TuBB-9-FITC, inside the cells and cell shells. The research applied photochemical internalization in delivering TuBB-9-FITC into cells, while the latter was able to control the key protein Ki-67, responsible for cell aggregation. Additionally, it used the photodynamic method to activate the FITC in the conjugates to photoinactivate Ki-67 so as to kill the tumor cells. The research is a successful attempt into new targeted photodynamic therapy via targeted Ki-67.

For more information on the paper, please visit

http://pubs.acs.org/doi/abs/10.1021/acs.molpharmaceut.5b00260