Scientists Improve Pancreatic Cancer Diagnosis with Multifunctional Platinum Nanoreactor
Metabolic analysis features ongoing biological pathways and can be more distal over proteomic/genomic approaches for in vitro diagnostics (IVD). However, point-of-care (POC) metabolic analysis needs designed materials to detect target biomarkers of low concentration in complex bio-systems.
Scientists from Shanghai Jiao Tong University and the Dalian Institute of Chemical Physics (DICP) of the Chinese Academy of Sciences (CAS) developed a multifunctional platinum nanoreactor towards POC metabolic analysis, for visual detection and mass spectrometry (MS) fingerprinting simultaneously. Their findings were recently published in Matter.
Schematic workflow of the multifunctional Pt platform. (Image by HUANG Lin)
Pt nanoreactor was designed with controlled core-shell structure and morphology for the visual detection of metabolic biomarkers and direct laser desorption/ionization MS fingerprinting of the native serum. The molecular mechanism of efficient catalytic processes in 5 min for visual quantitation of metabolic biomarkers was also investigated. In particular, the platform enabled biopsy-free diagnosis of pancreatic cancer patients with sensitivity of 84% and specificity of 92%.
The scientists further identified a potential panel of five biomarkers, may shed light on the progression monitoring in response to therapy.
“It is a minimally-invasive, high throughput, and fast platform, improving accessibility to disease diagnosis.” said prof. QIAN Kun
This vision of the development of on-site and on-time diagnostics based on these nanoreactors, enhancing the performance of POC devices towards personalized medicines and diverse diseases in near future.” prof. LIU Jian added.