Scientists Improve Pancreatic Cancer Diagnosis with Multifunctional Platinum Nanoreactor

Updated: 2019-10-10

Metabolic analysis features ongoing biological pathways and can be more distal over proteomic/genomic approaches for in vitro diagnostics (IVD). However, point-of-care (POC) metabolic analysis needs designed materials to detect target biomarkers of low concentration in complex bio-systems.

Scientists from Shanghai Jiao Tong University and the Dalian Institute of Chemical Physics (DICP) of the Chinese Academy of Sciences (CAS) developed a multifunctional platinum nanoreactor towards POC metabolic analysis, for visual detection and mass spectrometry (MS) fingerprinting simultaneously. Their findings were recently published in Matter.

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Schematic workflow of the multifunctional Pt platform. (Image by HUANG Lin)

Pt nanoreactor was designed with controlled core-shell structure and morphology for the visual detection of metabolic biomarkers and direct laser desorption/ionization MS fingerprinting of the native serum. The molecular mechanism of efficient catalytic processes in 5 min for visual quantitation of metabolic biomarkers was also investigated. In particular, the platform enabled biopsy-free diagnosis of pancreatic cancer patients with sensitivity of 84% and specificity of 92%.

The scientists further identified a potential panel of five biomarkers, may shed light on the progression monitoring in response to therapy.

“It is a minimally-invasive, high throughput, and fast platform, improving accessibility to disease diagnosis.” said prof. QIAN Kun

This vision of the development of on-site and on-time diagnostics based on these nanoreactors, enhancing the performance of POC devices towards personalized medicines and diverse diseases in near future.” prof. LIU Jian added.